ISIS Neutron and Muon Source Data Journal

In situ SANS / Electrochemical Study of Redox Active 3D Bicontinuous Nanomaterials for Biosensors

Abstract: This proposal investigates materials we have developed to immobilise redox-active enzymes, based on 3D nanomaterials known as lipid cubic phases (LCP). We incorporate an electroactive amphiphilic redox shuttle that can diffuse within the lipid matrix between the electrode and the enzyme. These materials can be easily applied to an electrode surface, for applications in electrochemical biosensing. They currently suffer from problems in loss of activity with repeated cycling. In order to understand and overcome these problems, we require real-time SANS data during electrochemical cycling, with and without contrast-matching of the majority lipid component. The data will show the behaviour and segregation of the electroactive surfactant, to test different hypotheses for the mechanism underlying the degradation in performance, and therefore show strategies for molecular design to overcome it.

Public release date: 27 November 2025

Principal Investigator: Dr Adam Squires
Local Contact: Dr Leide Cavalcanti
Experimenter: Dr Emily Draper
Experimenter: Mr Wanli Liu
Experimenter: Mr joshua white
Experimenter: Dr Adam Milsom

DOI: 10.5286/ISIS.E.RB2220580-1

Parent DOI: 10.5286/ISIS.E.RB2220580

ISIS Experiment Number: RB2220580

Part Number: 1

Date of Experiment: 24 November 2022

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Adam Squires et al; (2022): In situ SANS / Electrochemical Study of Redox Active 3D Bicontinuous Nanomaterials for Biosensors, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220580-1